The MTN-003 or VOICE analysis will randomize roughly 4200 women to acquire a microbicide gel (1{c8625687c0bf5600d910179268251ff7018f455ca14102e16acc5b3c47565e7b} tenofovir gel or placebo) or a pill (Viread®, Truvada® or placebo). In distinction to the CAPRISA 004 analysis, the VOICE research will use gel daily. The VOICE research is powered to match placebo versus vigorous agent in every the oral and topical arms, nevertheless has additional restricted power to look at oral versus topical treatment. Topical and oral PREP have theoretical benefits and drawbacks that shall be evaluated throughout the VOICE research. It is perhaps imagined that oral PREP is also stronger than topical…